Hederacolchiside A1
Hederacolchiside A1
CAS: 106577-39-3
Molecular Formula: C47H76O16
Hederacolchiside A1 - Names and Identifiers
Hederacolchiside A1 - Physico-chemical Properties
| Molecular Formula | C47H76O16 |
| Molar Mass | 897.1 |
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 253-255℃ (methanol , water ) |
| Boling Point | 967.2±65.0 °C(Predicted) |
| Specific Rotation(α) | 0 (c, 2.97 in MeOH) |
| Solubility | Soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. |
| Appearance | White crystal |
| pKa | 4?+-.0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| In vitro study | Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) . |
| In vivo study | hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells. |
Hederacolchiside A1 - Reference Information
| biological activity | Hederacolchiside A1 is isolated from Pulsatilla chinensis and induces apoptosis by regulating PI3K/Akt/mTOR signaling pathway, thus inhibiting tumor cell proliferation. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro. |
| target | PI3K Akt mTOR |
| in vitro study | Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) . |
| in vivo study | hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells. |
Last Update：2024-04-09 21:49:45
Supplier List
Featured ProductsSpot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Hederacolchiside A1 Request for quotationCAS: 106577-39-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Hederacolchiside A1 Request for quotationCAS: 106577-39-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Hederacolchiside A1 Visit Supplier Webpage Request for quotationCAS: 106577-39-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Hederacolchiside A1
496-78-6
52320-67-9
52662-00-7
Piperaquine phosphate
Triiodoarsine
fennosanh30
Afusona
55044-38-7
24207-41-8
496-78-6
52320-67-9
52662-00-7
Piperaquine phosphate
Triiodoarsine
fennosanh30
Afusona
55044-38-7
24207-41-8